Higuchi connors phase solubility techniques.
Phase solubility studies in distilled water were conducted according to the method of Higuchi and Connors . Excess amounts of diosmin were added to a series of glass vials containing 10.0 mL of distilled water. ... Higuchi T, Connors KA. Phase solubility techniques. Adv. Anal. Chem. Instrum. 1965; 4:117–212. [Google Scholar] 26. Doile KM ...
Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE J Pharm Sci. 1964 Nov;53:1325-8. doi: 10.1002/jps.2600531108. Authors L W DITTERT, T HIGUCHI, D R REESE. PMID: 14253586 DOI: 10.1002/jps.2600531108 No abstract available. MeSH terms Chemistry, Pharmaceutical* ...Phase solubility measurements of SBE 7-β-CD and valsartan were performed using the Higuchi-Connors technique . In separate conical flasks holding 10 ml of distilled water having increasing concentrations of SBE 7 -β-CD starting from 0.5 to 5 mM, an excess of valsartan was added.Phase solubility studies of BDQ in the presence of SBE-β-CD was performed according to the method described by Higuchi and Connors [30] and previously ...HIGHLIGHTS Enhanced curcumin solubility up to 190 fold higher than pure curcumin was investigated The phase solubility results of curcumin range from 5.7×10-4 M-1 and 7.8×10-4 M-1 at 25 and 37 °C, respectively First time of novel dyeing test was performed with complex of curcumin, signified its solubility This study provides useful …
The phase solubility studies were performed according to the method described by Higuchi and. Connors [24]. Different concentrations of β-CD and HPβ-CD were ...PHASE-SOLUBILITY TECHNIQUES HIGUCHI TK,CONNORS A. Keyword. 出版时间：. 1965/01/01. 被引量：. 2861. 收藏 引用 批量引用 报错 分享. 全部来源 求助全文. ResearchGate scienceopen.com sid.ir. Abstract The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability.
In present work, phase solubility analysis were conducted for studying the solubility of terpineol, a natural flavor compound with antifungal and disinfectant action, in 2-hydroxypropyl-β-cyclodextrin (HBCD) and in β-cyclodextrin (BCD) aqueous solutions and for calculating the thermodynamic parameters involved in the complex formation.
Phase Solubility Study. Phase solubility study was carried out according to the Higuchi and Connors method . For phase solubility study of a binary system, an excess amount of PLDN was added to aqueous solutions containing increasing concentrations of β-CD (3–15 mM). The solutions were kept on rotary shaker for 48 h at 25 °C.T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .Article Original Paper Published: 08 August 2022 Mangiferin/ β -cyclodextrin complex: determination of the Inclusion constant in aqueous solution by Higuchi-Connors method and molecular absorption and photoluminescence UV spectroscopies at pH 3.4 Lucero Hernández-García, Alberto Rojas-Hernández & Annia Galano
Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has …
Phase solubility techniques. Author(s): T. Higuchi, KA Connors, S. L. Connors, K.A. Connors . Publication date: 1965. Read this article at. ScienceOpen Bookmark. There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Phase solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors (Higuchi et al., 1965). An excess amount of ALLO was added to the aqueous solutions of each carrier containing increasing concentrations of the individual carrier (i.e., 0, 1, 5, and 10 % w/v).Phase solubility studies for Cur/Na 2 GA systems were carried out in aqueous systems at different temperatures to calculate the ... (A L-type relationships), suggesting the formation of 1:1 ‘molecular relations’ of associated complexes/micelles (Higuchi & Connors, Citation 1965). Thus, ... Connors KA. (1965). Phase-solubility techniques. In: Reilley CN, ed. …Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …Methods: Phase solubility studies revealed Bs type plots and stability constant was found to be 1868.79 kg/mol. Saturation solubility of binary complexes of CP with NS revealed marginal increase in saturation solubility in various media. An increase of 14.61% and 17.11% was evident in biorelevant media.Grant DJW and Higuchi T. Solubility Behavior of Organic Compounds. Wiley, New York, NY, 1990. Google Scholar Higuchi T and Connors KA. Phase-Solubility Techniques. Advan Anal Chem Instr 1965; 4: 117–212. CAS Google Scholar Huang LF and Tong WQ.
13 Şub 2019 ... The phase solubility studies were carried out according to Higuchi and Connors. ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4 ...Phase solubility study. Phase-solubility study is a traditional and useful approach not only to determine the value of the stability constant, but also to give insight into the stoichiometry of the equilibrium. The practical and phenomenological implications of phase solubility study were developed by Higuchi and Connons (Higuchi & Connors ...24 Tem 2018 ... This phase-solubility technique was first developed by Higuchi and Connors. ... complex formation solubility, spectral and kinetic techniques. J ...The apparent solubility of the substrates (adenine, guanosine, acyclovir, or triamterene) was appreciably increased by forming complexes with the ligands (vitamins, amino acids, …The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...
T. Higuchi, K. A. Connors, "Phase Solubility Techniques," Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesThe phase solubility study was carried by the Higuchi and. Connors ... 2011 Jul 1;3(3):205-10. 27. Higuchi. T., Connors. K. phase solubility techniques.advanced.
2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …11 Tem 2017 ... Higuchi T, Connors KA. Phase solubility techniques. Advances in Analytical Chemistry and Instrumen- tation. New York, pp. 117–212 ...also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique. Research J. Pharm. and Tech. 2020; 13(10):4557-4564. doi: 10.5958/0974-360X.2020.00803.3 Cite(Electronic): Gaurav Bhaduka, Jitendra Singh Rajawat. Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique.The aqueous solubility of 1 linearly increased as a function of HP-β -CD concentration and showed features of an A -CD concentration and showed features of an AL type diagram. Thermodynamic parameters were obtained by using the temperature dependence of the stability constant at temperatures of between 25 and 37 type diagram.Phase-solubility measurements. Phase-solubility measurements were carried out according to the method of Higuchi and Connors.14 Excess amount of 5-NI. ( ...A phase-solubility study, where the drug (i.e. the substrate) solubility in moles/liter is plotted against the molar CD (i.e. the ligand) concentration, is one of the most common methods applied. Fig. 3 displays the effects CDs can have on drug solubility and the classification of the profiles ( Higuchi and Connors, 1965 ).The plotted diagram displays a straight line with slopes less than 1, suggesting characteristic of Higuchi A L type. This indicate the formation of a 1:1 molecular ratio between the API and the CD. Using the Higuchi–Connors equation, the apparent solubility constant (K C) was determined from Fig. 1, resulting in a value of 122.01 M-1.
Higuchi T, Connors KA. Adv anal chem instrum. Phase-solubility Techniques. 1965;. 4:117-212. 10. Zingone G, Rubessa F. Preformulation study of the inclusion ...
[Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.
Phase-solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors [13]. An excess amount of CAR was added to the aqueous solutions of Soluplus® in water containing increasing concentrations of Soluplus® (0–20% w/v).Jun 15, 2019 · Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ... Phase solubility techniques @inproceedings{Higuchi1965PhaseST, title={Phase solubility techniques}, author={Takeru. Higuchi and Andrew L. Connors}, year={1965}, url={https://api.semanticscholar.org/CorpusID:100897505} } T. Higuchi, A. Connors; Published 1965; ChemistryPhase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Phase-solubility analysis. Phase-solubility study was carried out according to the method of Higuchi and Connors . Excess amount of repaglinide (approx. 10 mg) was added to 2.5 mL 10 mM phosphate buffer (pH 6 and pH 3.5) containing increasing amounts of Captisol ® (10 −3 –10 −1 M) and shaken at 25 ± 0.5 °C.The present study was aimed to formulate the solid dispersion incorporated microcapsule to improve the dissolution rate and half life of pioglitazone hydrochloride. The solvent evaporation method was used to formulate the solid dispersion resulted increased dissolution rate, bioavailability and stability. Finally increase the half life of the ... 2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...Phase solubility curve of Sbio. Previously, the Higuchi-Connors phase-solubility method was used for assessing the compound stability constant (Higuchi & Connors, 1965). Briefly, extra Sbio was mixed with deionized water (Master-S, Hitech-sciencetool, Shanghai, PR China) containing 0–10 mM γ-CD. Then the suspensions …Moreover, phase-solubility analysis shows that propyl-paraben and ethylparaben, at room temperature, can also form solid solutions whose solubility is related to the composition of the solid phase at equilibrium. ... T. Higuchi, A. Connors. Phase-solubility Techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus …
31 Ağu 2017 ... The phase solubility studies were carried out to study the effect of cyclodextrins according to the method described by Higuchi and Connors. The ...According to the classification method of Higuchi and Connors (Chen et al., Citation 2007; Higuchi & Connors, Citation 1965), ... Phase-solubility techniques. Adv Chem Instrum 4:117–212 [Google Scholar] Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet.One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. The mole fraction solubility of TDL was found to be highest in pure PEG 400 (1.86 × 10- 2 at 298.15 K) as compared to water (5.7 × 10- 7 at 298.15 K). The thermophysical parameters such as enthalpies and entropies for TDL dissolution indicated that the dissolution of TDL is endothermic and an entropy-driven process.Instagram:https://instagram. ma design managementday choghadiyadot product 3d vectorsabeka business math test 10 Phase solubility study. Phase-solubility study is a traditional and useful approach not only to determine the value of the stability constant, but also to give insight into the stoichiometry of the equilibrium. The practical and phenomenological implications of phase solubility study were developed by Higuchi and Connons (Higuchi & Connors ... ap lit unit 1 progress check mcqsports.bet9ja.com Phase Solubility Studies. Phase solubility studies were carried out based on the methods described by Higuchi and Connors . Excess amount of POS (30 mg) was added to aqueous solutions of β-CD and DM-β-CD with various concentrations (0 to 15.00 mM for β-CD and 0 to 35.00 mM for DM-β-CD).Phase solubility studies. Phase solubility studies of stigmasterol with different concentrations of α-CD were determined by the method proposed by Higuchi and Connors at room temperature. The excess amount of stigmasterol was dissolved in 60 ml of ethanol and then added to 10 ml of double-distilled water containing various concentrations of α ... craigslist pullman pets The objective of this study was to learn whether or not the pattern recognition methods, such as agglomerative cluster analysis (CA) and principal component analysis (PCA), can be used as supplementary techniques for identification of salicylamide (SAA) inclusion complexes with β-cyclodextrin (β-CD) and 2-hydroxypropyl-β-cyclodextrin (HP …T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117-212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135-149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...